Mechanism of Action, Precautions, and Considerations While Using Levitra
Erectile Dysfunction, characterized by the inability to achieve or maintain a satisfactory penile erection, falls under the category of medications known as Phosphodiesterase inhibitors. Levitra (vardenafil hydrochloride) is a medication used to address erectile dysfunction by inhibiting a specific enzyme (phosphodiesterase-PDE5).
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How does Levitra work?
The mode of operation of this medication is similar to that of Viagra and Tadalafil. Penile erection relies on the circulation of blood into the penile tissues. Enhanced blood flow in the blood vessels of the penis leads to engorgement of the penis as the vessels expand.
Simultaneously, the constriction of blood vessels responsible for carrying blood away from the penis decreases, reducing the outflow of blood from these arteries, which aids in sustaining the erection.
The initial step in the engorgement of penile blood vessels during sexual stimulation involves the release of nitric oxide in the penis. Nitric oxide triggers the production of guanylate cyclase, which in turn generates cyclic guanosine monophosphate (cGMP).
This enzyme, cGMP, regulates the dilation and constriction of blood vessels, thereby controlling blood flow in the penis. Levitra works by inhibiting the phosphodiesterase-5 (PDE-5) enzyme, which normally breaks down cGMP.
By preventing the degradation of cGMP, Levitra helps maintain its levels in the body for an extended period. This prolonged presence of cGMP leads to sustained penile engorgement, prolonging the duration of the erection.
Precautions to remember
Certain medications can potentially produce undesirable or risky effects when taken alongside Levitra. It is essential to inform your doctor about all other medications you are taking, particularly riociguat (Adempas).
This communication is crucial for your safety and to ensure that any potential interactions between medications are identified and managed appropriately.
Avoid taking Levitra if you are also using nitrate medication for chest pain or heart issues, including nitro-glycerine, isosorbide dinitrate, isosorbide mononitrate, and certain recreational drugs like “poppers.” Combining vardenafil with nitrate medicine can result in a sudden and severe drop in blood pressure, which can be dangerous.
Contact your doctor immediately or seek emergency medical attention if you experience a painful erection lasting longer than 4 hours. Prolonged erection, known as priapism, can cause damage to the penis and requires prompt medical intervention.
Discontinue the use of this medication and seek emergency medical assistance if you experience sudden vision loss.
If you feel nauseated or dizzy during sexual act or develop chest, arm, neck, or jaw pain, numbness, or tingling, stop immediately and contact your doctor. These symptoms could indicate a serious side effect requiring prompt medical attention.
Therefore, while evaluating the effectiveness of Levitra, it is crucial to consider potential ocular side effects of Levitra associated with its usage.
What should be avoided while using Levitra?
Grapefruit, Seville oranges, and alcohol can amplify side effects of vardenafil. Avoid them. Only use impotence treatments as prescribed by your doctor to prevent adverse interactions.
